6-Bromo-4-(trifluoromethyl)quinolin-2(1H)-one

Name: 6-Bromo-4-(trifluoromethyl)quinolin-2(1H)-one
Brand: ChemScene
Availability: InStock
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CAS No. 328955-61-9
Cat. No. CS-0041128
Molecule weight292.05
Purity≥98%
MDL No.MFCD11846359

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Bromo-4-(trifluoromethyl)quinolin-2(1H)-one|CS-0041128

Structure of 328955-61-9

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General Information

CAS No. 328955-61-9
Cat. No. CS-0041128
Purity ≥98%
MDL No. MFCD11846359
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₅BrF₃NO
Molecular Weight 292.05
Synonym(s) 6-broMo-4-trifluoroMethylquinolin-2(1H)-one
SMILES O=C1NC2=C(C=C(Br)C=C2)C(C(F)(F)F)=C1

Description

6-Bromo-4-(trifluoromethyl)quinolin-2(1H)-one is a fluorinated quinolinone scaffold featuring a bromine substituent at the 6-position and a trifluoromethyl group at the 4-position. This electron-deficient heterocycle serves as a strategic building block in medicinal chemistry, enabling direct C–H functionalization and facilitating access to complex polycyclic architectures through palladium-catalyzed cross-coupling reactions.

Application

6-Bromo-4-(trifluoromethyl)quinolin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromo substituent and electron-deficient quinolinone core. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the keto functionality supports further functionalization. This compound exhibits good bench stability and is compatible with standard purification methods, facilitating integration into multi-step synthesis workflows for bioactive heterocycles.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 32.86
LogP 3.3094
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

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6-Bromo-4-(trifluoromethyl)quinolin-2(1H)-one

CAS No. 328955-61-9

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