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CS-W001157 4
Total: USD 88.00

4-(Trifluoromethyl)phenylacetic acid

  • CAS No. 32857-62-8

  • Cat. No. CS-W015432
  • Purity≥98%
  • MDL No.MFCD00004352

*For research and further manufacturing use only, not for direct human use.

4-(Trifluoromethyl)phenylacetic acid|CS-W015432

Structure of 32857-62-8

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General Information

  • CAS No. 32857-62-8
  • Cat. No. CS-W015432
  • Purity ≥98%
  • MDL No. MFCD00004352
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇F₃O₂
  • Molecular Weight 204.15
  • Synonym(s) p-(Trifluoromethyl)phenylacetic acid
  • SMILES C1=C(C=CC(=C1)CC(O)=O)C(F)(F)F

Description

4-(Trifluoromethyl)phenylacetic acid features a trifluoromethyl group that imparts strong electron-withdrawing character and enhanced metabolic stability. This aromatic carboxylic acid integrates readily into pharmaceutical scaffolds, offering improved lipophilicity and bioavailability in drug discovery applications.

Synthesis

  • Route1
    • null|null
      124-38-9
    • null|null
      939-99-1
    • ~75%
    • In-stock
      4-(Trifluoromethyl)phenylacetic acid|CS-W015432
      32857-62-8

    References

    • Leon, Thierry; Correa, Arkaitz; Martin, Ruben Journal of the American Chemical Society, 2013 , vol. 135, # 4 p. 1221 - 1224
  • Route2
    • null|null
      512787-33-6
    • ~89%
    • In-stock
      4-(Trifluoromethyl)phenylacetic acid|CS-W015432
      32857-62-8

    References

    • Huh, Dal Ho; Jeong, Ji Sang; Lee, Hee Bong; Ryu, Hoejin; Kim, Young Gyu Tetrahedron, 2002 , vol. 58, # 50 p. 9925 - 9932
  • Route3
    • 2-(4-(Carboxymethyl)phenyl)-2,2-difluoroacetic acid|CS-0446448
      1436389-36-4
    • ~17%
    • null|null
      62037-86-9
    • In-stock
      4-(Trifluoromethyl)phenylacetic acid|CS-W015432
      32857-62-8

    References

    • Organic Letters, , vol. 15, # 11 p. 2648 - 2651

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.3325
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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