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CS-W001157 4
Total: USD 88.00

Ethyl 3-methyl-1H-pyrrole-2-carboxylate

  • CAS No. 3284-47-7

  • Cat. No. CS-D1589
  • Purity≥98%
  • MDL No.MFCD01006747

*For research and further manufacturing use only, not for direct human use.

Ethyl 3-methyl-1H-pyrrole-2-carboxylate|CS-D1589

Structure of 3284-47-7

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General Information

  • CAS No. 3284-47-7
  • Cat. No. CS-D1589
  • Purity ≥98%
  • MDL No. MFCD01006747
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁NO₂
  • Molecular Weight 153.18
  • Synonym(s) 3-Methyl-1H-pyrrole-2-carboxylic acid ethyl ester; Ethyl 3-methyl-1H-pyrrole-2-carboxylate; Ethyl 3-methylpyrrole-2-carboxylate; Pyrrole-2-carboxylic acid, 3-methyl-, ethyl ester
  • SMILES O=C(C1=C(C)C=CN1)OCC

Description

Ethyl 3-methyl-1H-pyrrole-2-carboxylate features a sterically hindered pyrrole core with a methyl group at the 3-position and an ethyl ester at C2, enhancing solubility and reactivity. This bench-stable heterocycle integrates readily into synthetic sequences requiring electron-rich pyrrolic scaffolds.

Application

Ethyl 3-methyl-1H-pyrrole-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyrroles via standard functional group manipulations. Its ester functionality facilitates selective transformations, while the methyl substituent enhances regiochemical control. The compound exhibits good bench stability and compatibility with common coupling reactions, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • Ethyl 3-Hydroxy-3-methyl-1-tosylpyrrolidine-2-carboxylate|CS-0766338
      3284-52-4
    • ~79%
    • In-stock
      Ethyl 3-methyl-1H-pyrrole-2-carboxylate|CS-D1589
      3284-47-7

    References

    • PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; TRUSTEES OF BOSTON UNIVERSITY Patent: WO2009/23272 A1, 2009 ; Location in patent: Page/Page column 36 ;
  • Route2
    • null|null
      3284-53-5
    • ~95%
    • In-stock
      Ethyl 3-methyl-1H-pyrrole-2-carboxylate|CS-D1589
      3284-47-7

    References

    • SEPRACOR INC. Patent: US2005/143443 A1, 2005 ; Location in patent: Page/Page column 39-41 ;
  • Route3
    • null|null
      1188476-68-7
    • ~%
    • In-stock
      Ethyl 3-methyl-1H-pyrrole-2-carboxylate|CS-D1589
      3284-47-7

    References

    • WO2009/117421 A2, ; Page/Page column 218 ; WO 2009/117421 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   42.09
  • LogP   1.49982
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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