4-Ethyl-2,6-difluorophenol

Name: 4-Ethyl-2,6-difluorophenol
Brand: ChemScene
Availability: InStock
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CAS No. 326493-68-9
Cat. No. CS-0152541
Purity≥98%
MDL No.MFCD28163189

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 326493-68-9

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Description

4-Ethyl-2,6-difluorophenol features a fluorinated aromatic ring with orthogonal electron-withdrawing and steric influences, enabling selective functionalization in complex synthesis. The para-fluoro substituents enhance reactivity at the ortho position, while the ethyl group provides solubility and steric modulation. This compound serves as a key intermediate in medicinal chemistry and agrochemical development.

Application

4-Ethyl-2,6-difluorophenol serves as a versatile building block for fluorinated aromatic scaffolds, enabling efficient functionalization in medicinal chemistry and agrochemical synthesis. Its ortho-fluorine substituents facilitate nucleophilic aromatic substitution, while the phenolic OH group allows for derivatization via esterification or ether formation. The ethyl group provides steric and electronic modulation, enhancing metabolic stability and lipophilicity in target molecules. Bench-stable and readily purified by distillation or recrystallization, it functions reliably in standard coupling and cyclization workflows.

General Information

CAS No. 326493-68-9
Cat. No. CS-0152541
Purity ≥98%
MDL No. MFCD28163189
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈F₂O
Molecular Weight 158.15
Synonym(s) Phenol, 4-ethyl-2,6-difluoro- (9CI)
SMILES CCC1=CC(=C(C(=C1)F)O)F

Computational Chemistry Data

TPSA 20.23
LogP 2.2328
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Ethyl-2,6-difluorophenol

CAS No. 326493-68-9

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