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CS-W001157 4
Total: USD 88.00

4-Ethyl-2,6-difluorophenol

  • CAS No. 326493-68-9

  • Cat. No. CS-0152541
  • Molecule weight158.15
  • Purity≥98%
  • MDL No.MFCD28163189

*For research and further manufacturing use only, not for direct human use.

4-Ethyl-2,6-difluorophenol|CS-0152541

Structure of 326493-68-9

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General Information

  • CAS No. 326493-68-9
  • Cat. No. CS-0152541
  • Purity ≥98%
  • MDL No. MFCD28163189
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₂O
  • Molecular Weight 158.15
  • Synonym(s) Phenol, 4-ethyl-2,6-difluoro- (9CI)
  • SMILES CCC1=CC(=C(C(=C1)F)O)F

Description

4-Ethyl-2,6-difluorophenol features a fluorinated aromatic ring with orthogonal electron-withdrawing and steric influences, enabling selective functionalization in complex synthesis. The para-fluoro substituents enhance reactivity at the ortho position, while the ethyl group provides solubility and steric modulation. This compound serves as a key intermediate in medicinal chemistry and agrochemical development.

Application

4-Ethyl-2,6-difluorophenol serves as a versatile building block for fluorinated aromatic scaffolds, enabling efficient functionalization in medicinal chemistry and agrochemical synthesis. Its ortho-fluorine substituents facilitate nucleophilic aromatic substitution, while the phenolic OH group allows for derivatization via esterification or ether formation. The ethyl group provides steric and electronic modulation, enhancing metabolic stability and lipophilicity in target molecules. Bench-stable and readily purified by distillation or recrystallization, it functions reliably in standard coupling and cyclization workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.2328
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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