tert-Butyl (4-amino-3-methylphenyl)carbamate

Name: tert-Butyl (4-amino-3-methylphenyl)carbamate
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CAS No. 325953-41-1
Cat. No. CS-0153191
Molecule weight222.28
Purity≥97%
MDL No.MFCD05663969

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl (4-amino-3-methylphenyl)carbamate|CS-0153191

Structure of 325953-41-1

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General Information

CAS No. 325953-41-1
Cat. No. CS-0153191
Purity ≥97%
MDL No. MFCD05663969
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₈N₂O₂
Molecular Weight 222.28
Synonym(s) tert-butyl 4-amino-3-methylphenylcarbamate
SMILES CC1=CC(=CC=C1N)NC(=O)OC(C)(C)C

Description

tert-Butyl (4-amino-3-methylphenyl)carbamate features a para-amino group flanked by a meta-methyl substituent on the aromatic ring, delivering enhanced electron density for coupling reactions. The tert-butyl carbamate moiety provides robust protection of the amine under standard conditions, enabling stable incorporation into complex scaffolds during peptide and small-molecule synthesis.

Application

tert-Butyl (4-amino-3-methylphenyl)carbamate serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted anilines and heterocyclic scaffolds. The tert-butyl carbamate group provides excellent stability under basic conditions and facilitates straightforward deprotection via mild acid treatment. Its ortho-methyl and para-amino substituents offer defined regiochemistry for downstream coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig aminations, making it well-suited for pharmaceutical intermediate development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 64.35
LogP 2.92422
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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tert-Butyl (4-amino-3-methylphenyl)carbamate

CAS No. 325953-41-1

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