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3-Aminopyrazine-2-carboxamide

  • CAS No. 32587-10-3

  • Cat. No. CS-0149924
  • Purity≥96%
  • MDL No.MFCD03407446

*For research and further manufacturing use only, not for direct human use.

3-Aminopyrazine-2-carboxamide|CS-0149924

Structure of 32587-10-3

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General Information

  • CAS No. 32587-10-3
  • Cat. No. CS-0149924
  • Purity ≥96%
  • MDL No. MFCD03407446
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₄O
  • Molecular Weight 138.13
  • Synonym(s) Pyrazinecarboxamide, 3-amino- (7CI,9CI)
  • SMILES NC1=C(C(N)=O)N=CC=N1

Description

3-Aminopyrazine-2-carboxamide features a fused pyrazine core with complementary amine and carboxamide groups, enabling versatile integration into bioactive scaffolds. This electron-deficient heterocycle supports hydrogen bonding and metal coordination, enhancing binding affinity in pharmaceutical and materials applications. The molecule exhibits bench-stable handling under standard conditions.

Application

3-Aminopyrazine-2-carboxamide serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of kinase inhibitors and other bioactive scaffolds. Its dual amine and amide functionalities offer orthogonal reactivity for sequential derivatization, while its planar structure enhances target binding affinity. Bench-stable and readily purified by recrystallization, it functions effectively in standard coupling reactions and facilitates modular synthesis of complex pyrazine-based APIs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   94.89
  • LogP   -0.8423
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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