Bis(3,5-di-tert-butylphenyl)phosphine oxide

Name: Bis(3,5-di-tert-butylphenyl)phosphine oxide
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 325773-65-7
Cat. No. CS-0098799
Purity≥95%
MDL No.MFCD08458886

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Bis(3,5-di-tert-butylphenyl)phosphine oxide|CS-0098799

Structure of 325773-65-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 325773-65-7
Cat. No. CS-0098799
Purity ≥95%
MDL No. MFCD08458886
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₈H₄₃OP
Molecular Weight 426.61
Synonym(s) None
SMILES O=P(C1=CC(C(C)(C)C)=CC(C(C)(C)C)=C1)C2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2

Description

Bis[3,5-bis(1,1-dimethylethyl)phenyl]phosphine oxide features a sterically shielded phosphine oxide core that enhances stability and reduces unwanted coordination. The bulky 2,6-diisopropylphenyl groups provide exceptional resistance to oxidation and moisture, enabling reliable use in catalytic systems and as a ligand scaffold under demanding reaction conditions.

Application

Bis[3,5-bis(1,1-dimethylethyl)phenyl]phosphine oxide serves as a sterically hindered, bench-stable phosphine oxide widely used in palladium-catalyzed cross-coupling reactions. Its bulky aryl groups enhance solubility and reduce oxidation susceptibility, facilitating efficient ligand transfer in Suzuki-Miyaura and Negishi couplings. The molecule functions as a robust precursor to the corresponding phosphine, enabling reliable catalytic activity under mild conditions with excellent functional group tolerance.

Synthesis

Route1
- 762-04-9
- ~56%
- In-stock
  
  325773-65-7
References
- Takeda Chemical Industries, Ltd. Patent: EP1452537 A1, 2004 ; Location in patent: Page 32 ;
Route2
- In-stock
  
  22385-77-9
- ~%
- In-stock
  
  325773-65-7
References
- Organic Process Research and Development, , vol. 15, # 5 p. 1178 - 1184

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 17.07
LogP 7.3871
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 2

Key Words

325773-65-7 sigma325773-65-7 manufacturer325773-65-7 price325773-65-7 structure325773-65-7 SDSbuy 325773-65-7325773-65-7 supplier325773-65-7 uses325773-65-7 molecular weightprice of 325773-65-7325773-65-7 chemical name formula of 325773-65-7

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Bis(3,5-di-tert-butylphenyl)phosphine oxide

CAS No. 325773-65-7

Recommended Products