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CS-W001157 4
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3-Fluorothiophene-2-carboxylic acid

  • CAS No. 32431-84-8

  • Cat. No. CS-W003072
  • Purity≥95%
  • MDL No.MFCD03426911

*For research and further manufacturing use only, not for direct human use.

3-Fluorothiophene-2-carboxylic acid|CS-W003072

Structure of 32431-84-8

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General Information

  • CAS No. 32431-84-8
  • Cat. No. CS-W003072
  • Purity ≥95%
  • MDL No. MFCD03426911
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃FO₂S
  • Molecular Weight 146.14
  • Synonym(s) 3-Fluoro-2-thiophenecarboxylic acid
  • SMILES OC(=O)c1sccc1F

Description

3-Fluorothiophene-2-carboxylic acid integrates a fluorine atom at the 3-position and a carboxylic acid group at the 2-position of a thiophene core. This combination imparts enhanced electron-withdrawing character and improved metabolic stability, making it valuable for constructing bioactive heterocycles in medicinal chemistry and materials science applications.

Application

3-Fluorothiophene-2-carboxylic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of fluorinated thiophene motifs into bioactive molecules. Its carboxylic acid functionality facilitates straightforward amide, ester, and acyl chloride derivatization, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and is compatible with standard coupling protocols, making it well-suited for high-throughput synthesis and scale-up applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.5854
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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