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CS-W001157 4
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(S)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid

  • CAS No. 324028-27-5

  • Cat. No. CS-0060983
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid|CS-0060983

Structure of 324028-27-5

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General Information

  • CAS No. 324028-27-5
  • Cat. No. CS-0060983
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₆F₃NO₄
  • Molecular Weight 319.28
  • Synonym(s) N-Boc-2,4,5-trifluoro-L-phenylalanine
  • SMILES CC(C)(OC(N[C@H](C(O)=O)CC1=CC(F)=C(F)C=C1F)=O)C

Description

This chiral building block features a bench-stable tert-butoxycarbonyl-protected amine and a sterically hindered trifluorophenyl group, enabling direct incorporation into peptide syntheses and bioactive molecule scaffolds under standard conditions.

Application

(S)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid serves as a valuable chiral building block for peptide and medicinal chemistry applications. The tert-butyl ester group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The 2,4,5-trifluorophenyl moiety enhances metabolic stability and modulates lipophilicity, while the α-amino acid framework enables efficient coupling reactions in solid-phase and solution-phase synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   2.6243
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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