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CS-W001157 4
Total: USD 88.00

4'-Fluoro-[1,1'-biphenyl]-4-ol

  • CAS No. 324-94-7

  • Cat. No. CS-W016809
  • Purity≥98%
  • MDL No.MFCD01830385

*For research and further manufacturing use only, not for direct human use.

4'-Fluoro-[1,1'-biphenyl]-4-ol|CS-W016809

Structure of 324-94-7

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General Information

  • CAS No. 324-94-7
  • Cat. No. CS-W016809
  • Purity ≥98%
  • MDL No. MFCD01830385
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₉FO
  • Molecular Weight 188.20
  • Synonym(s) 4-Hydroxy-4'-fluorobiphenyl
  • SMILES OC1=CC=C(C2=CC=C(F)C=C2)C=C1

Description

4'-Fluoro-[1,1'-biphenyl]-4-ol features a fluoro-substituted aryl group paired with a phenolic hydroxyl, enabling direct coupling in Suzuki-Miyaura and Ullmann reactions. This bench-stable scaffold integrates readily into bioactive molecules, offering enhanced metabolic stability and controlled electron density for medicinal chemistry applications.

Application

4'-Fluoro-[1,1'-biphenyl]-4-ol serves as a versatile building block in medicinal chemistry, enabling efficient Suzuki-Miyaura coupling due to its ortho-fluorinated aryl halide functionality. The phenolic hydroxyl group provides a handle for derivatization and metal complexation, while the biphenyl scaffold offers rigidity and π-stacking potential. Bench-stable and compatible with diverse reaction conditions, it facilitates rapid access to functionalized biaryl scaffolds relevant to pharmaceutical development.

Synthesis

  • Route1
    • null|null
      106-41-2
    • In-stock
      4-Fluorobenzeneboronic acid|CS-D1103
      1765-93-1
    • ~98%
    • In-stock
      4'-Fluoro-[1,1'-biphenyl]-4-ol|CS-W016809
      324-94-7

    References

    • Liu, Ping; Yan, Mei; He, Ren Applied Organometallic Chemistry, 2010 , vol. 24, # 2 p. 131 - 134
  • Route2
    • null|null
      540-38-5
    • In-stock
      4-Fluorobenzeneboronic acid|CS-D1103
      1765-93-1
    • ~97%
    • In-stock
      4'-Fluoro-[1,1'-biphenyl]-4-ol|CS-W016809
      324-94-7

    References

    • Sakurai, Hidehiro; Tsukuda, Tatsuya; Hirao, Toshikazu Journal of Organic Chemistry, 2002 , vol. 67, # 8 p. 2721 - 2722
  • Route3

    References

    • Steiniger, Bjoern; Wuest, Frank R. Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 9 p. 817 - 827

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   3.1983
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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