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CS-W001157 4
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2-(Methylamino)-3-pyridinemethanol

  • CAS No. 32399-12-5

  • Cat. No. CS-W023173
  • Molecule weight138.17
  • Purity≥96%
  • MDL No.MFCD06254696

*For research and further manufacturing use only, not for direct human use.

2-(Methylamino)-3-pyridinemethanol|CS-W023173

Structure of 32399-12-5

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General Information

  • CAS No. 32399-12-5
  • Cat. No. CS-W023173
  • Purity ≥96%
  • MDL No. MFCD06254696
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) 2-(Methylamino)-3-pyridinemethanol; 2-(N-Methylamino)-3-hydroxymethylpyridine; [2-(Methylamino)-3-pyridyl]methanol; 2-(Methylamino)pyridine-3-methanol
  • SMILES OCC1=CC=CN=C1NC

Description

2-(Methylamino)-3-pyridinemethanol features a pyridine ring bearing a methylamino group at the 2-position and a hydroxymethyl substituent at the 3-position. This configuration imparts enhanced solubility and polarity, enabling efficient integration into bioactive scaffolds. The molecule exhibits bench-stable behavior under standard conditions and serves as a direct precursor in medicinal chemistry for kinase inhibitors and neuroactive compounds.

Application

2-(Methylamino)-3-pyridinemethanol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through standard functional group transformations. Its pendant hydroxyl and N-methylpyridyl groups offer orthogonal reactivity for derivatization, while the molecule exhibits good bench stability and ease of purification—ideal for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Ohwada, Jun; Tsukazaki, Masao; Hayase, Tadakatsu; Oikawa, Nobuhiro; Isshiki, Yoshiaki; Fukuda, Hiroshi; Mizuguchi, Eisaku; Sakaitani, Masahiro; Shiratori, Yasuhiko; Yamazaki, Toshikazu; Ichihara, Shigeyasu; Umeda, Isao; Shimma, Nobuo Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 191 - 196
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 33, # 10 p. 2697 - 2706
  • Route3
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    • In-stock
      2-(Methylamino)-3-pyridinemethanol|CS-W023173
      32399-12-5

    References

    • US6812238 B1, ; Page/Page column 21-24; 36 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   45.15
  • LogP   0.6156
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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