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CS-W001157 4
Total: USD 88.00

(S)-2-(2,2-Dimethyl-[1,3]dioxolan-4-yl)ethanol

  • CAS No. 32233-43-5

  • Cat. No. CS-0052112
  • Purity≥89%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-2-(2,2-Dimethyl-[1,3]dioxolan-4-yl)ethanol|CS-0052112

Structure of 32233-43-5

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General Information

  • CAS No. 32233-43-5
  • Cat. No. CS-0052112
  • Purity ≥89%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄O₃
  • Molecular Weight 146.18
  • Synonym(s) (S)-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethanol
  • SMILES CC1(C)OC[C@H](CCO)O1

Application

(S)-2-(2,2-Dimethyl-[1,3]dioxolan-4-yl)ethanol serves as a valuable chiral building block in asymmetric synthesis, leveraging the stable 1,3-dioxolane ring to protect aldehyde functionality. The molecule enables controlled introduction of stereodefined hydroxyl and alkyl functionalities, facilitating efficient transformations in medicinal chemistry and natural product synthesis. Its bench-stable nature and compatibility with a broad range of reaction conditions make it well-suited for multi-step synthetic sequences requiring high stereochemical fidelity.

Synthesis

  • Route1
    • Methyl (S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)acetate|CS-0318973
      95422-24-5
    • ~99%
    • In-stock
      (S)-2-(2,2-Dimethyl-[1,3]dioxolan-4-yl)ethanol|CS-0052112
      32233-43-5

    References

    • Tursun, Ahmatjan; Canet, Isabelle; Aboab, Bettina; Sinibaldi, Marie-Eve Tetrahedron Letters, 2005 , vol. 46, # 13 p. 2291 - 2294
  • Route2
    • null|null
      42890-76-6
    • ~85%
    • In-stock
      (S)-2-(2,2-Dimethyl-[1,3]dioxolan-4-yl)ethanol|CS-0052112
      32233-43-5

    References

    • Daiso Co., Ltd. Patent: US6620977 B1, 2003 ;
  • Route3
    • null|null
      42890-76-6
    • null|null
      67-64-1
    • ~93%
    • In-stock
      (S)-2-(2,2-Dimethyl-[1,3]dioxolan-4-yl)ethanol|CS-0052112
      32233-43-5

    References

    • Nilewski, Christian; Deprez, Nicholas R.; Fessard, Thomas C.; Li, Dong Bo; Geisser, Roger W.; Carreira, Erick M. Angewandte Chemie - International Edition, 2011 , vol. 50, # 34 p. 7940 - 7943

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   0.5203
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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