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CS-W001157 4
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Pyrido[2,3-b]pyrazine

  • CAS No. 322-46-3

  • Cat. No. CS-0072745
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Pyrido[2,3-b]pyrazine|CS-0072745

Structure of 322-46-3

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General Information

  • CAS No. 322-46-3
  • Cat. No. CS-0072745
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅N₃
  • Molecular Weight 131.13
  • Synonym(s) Pyridopyrazine
  • SMILES C12=NC=CC=C1N=CC=N2

Description

Pyrido[2,3-b]pyrazine is a nitrogen-rich heterocyclic scaffold featuring fused pyridine and pyrazine rings, offering enhanced electron deficiency and planar rigidity. This structure enables effective integration into functional materials and pharmaceutical intermediates, particularly in applications requiring strong π-stacking and metabolic stability.

Application

Pyrido[2,3-b]pyrazine serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling the construction of bioactive molecules through established coupling and functionalization protocols. Its planar, electron-deficient structure facilitates metal-catalyzed cross-couplings and offers favorable solubility and stability for synthetic optimization. Widely used in kinase inhibitor and CNS-targeted drug discovery, it functions as a core building block with predictable reactivity and excellent compatibility in multi-step synthesis.

Synthesis

  • Route1

    References

    • Venuti, Michael C. Synthesis, 1982 , # 1 p. 61 - 63
  • Route2

    References

    • Chemistry - A European Journal, , vol. 13, # 6 p. 1754 - 1762
  • Route3

    References

    • Journal of the Chemical Society, , p. 1389,1392 Journal of the Chemical Society, , p. 303,307

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.67
  • LogP   1.0248
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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