2-Chloro-5-(methylsulfonyl)pyrimidine

Name: 2-Chloro-5-(methylsulfonyl)pyrimidine
Brand: ChemScene
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CAS No. 321565-33-7
Cat. No. CS-0526717
Purity≥98%
MDL No.MFCD21879442

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-(methylsulfonyl)pyrimidine|CS-0526717

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General Information

CAS No. 321565-33-7
Cat. No. CS-0526717
Purity ≥98%
MDL No. MFCD21879442
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂O₂S
Molecular Weight 192.62
Synonym(s) 2-chloro-5-methanesulfonylpyrimidine
SMILES O=S(C1=CN=C(Cl)N=C1)(C)=O

Description

2-Chloro-5-(methylsulfonyl)pyrimidine serves as a key electrophilic scaffold in medicinal chemistry, featuring a chlorine atom at C2 and a methylsulfonyl group at C5. This combination imparts enhanced solubility and metabolic stability, enabling efficient coupling in cross-coupling reactions and facilitating the construction of complex heterocyclic architectures under standard conditions.

Application

2-Chloro-5-(methylsulfonyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient C–H functionalization and late-stage derivatization. Its chloro group facilitates nucleophilic substitution with amines, thiols, and heterocycles under mild conditions, while the methylsulfonyl moiety enhances solubility and metabolic stability. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, simplifying purification and scale-up in API synthesis workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

TPSA 59.92
LogP 0.5335
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

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2-Chloro-5-(methylsulfonyl)pyrimidine

CAS No. 321565-33-7

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