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6-Bromo-4-hydroxyquinazoline

  • CAS No. 32084-59-6

  • Cat. No. CS-D1073
  • Purity≥97%
  • MDL No.MFCD01219541

*For research and further manufacturing use only, not for direct human use.

6-Bromo-4-hydroxyquinazoline|CS-D1073

Structure of 32084-59-6

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General Information

  • CAS No. 32084-59-6
  • Cat. No. CS-D1073
  • Purity ≥97%
  • MDL No. MFCD01219541
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂O
  • Molecular Weight 225.04
  • Synonym(s) 6-Bromoquinazolin-4-ol; 6-bromoquinazolin-4(1H)-one
  • SMILES O=C1NC=NC2=C1C=C(Br)C=C2

Description

6-Bromo-4-hydroxyquinazoline features a bromine atom at the 6-position and a hydroxyl group at the 4-position, enabling direct functionalization in C–H activation and cross-coupling reactions. This electron-deficient scaffold integrates readily into kinase inhibitor frameworks and serves as a key intermediate in medicinal chemistry campaigns targeting purine analogs.

Application

6-Bromo-4-hydroxyquinazoline serves as a versatile building block for the synthesis of bioactive quinazoline derivatives. The bromo group enables palladium-catalyzed cross-coupling reactions, while the hydroxyl functionality provides a site for derivatization or protection. This compound exhibits good bench stability and facilitates efficient access to kinase inhibitor scaffolds through standard coupling and cyclization protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   1.6856
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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