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CS-W001157 4
Total: USD 88.00

tert-Butyl (2-(isopropylamino)ethyl)carbamate

  • CAS No. 320580-88-9

  • Cat. No. CS-0309306
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (2-(isopropylamino)ethyl)carbamate|CS-0309306

Structure of 320580-88-9

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General Information

  • CAS No. 320580-88-9
  • Cat. No. CS-0309306
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₂N₂O₂
  • Molecular Weight 202.29
  • Synonym(s) Tert-butyl 2-(isopropylamino)ethylcarbamate
  • SMILES CC(NCCNC(OC(C)(C)C)=O)C

Description

tert-Butyl (2-(isopropylamino)ethyl)carbamate features a robust tert-butyl carbamate protecting group paired with a strategically positioned isopropylaminoethyl chain, enabling selective N-alkylation and efficient deprotection under mild acidic conditions. This combination delivers enhanced stability and compatibility in complex peptide synthesis workflows.

Application

tert-Butyl (2-(isopropylamino)ethyl)carbamate serves as a versatile protected amine building block, enabling efficient access to bioactive amine-containing scaffolds. Its tert-butyl carbamate group provides excellent stability under basic conditions and facilitates selective deprotection via mild acidolysis. The isopropylaminoethyl moiety offers a readily functionalizable handle for downstream conjugation or cyclization, making it particularly useful in medicinal chemistry workflows requiring orthogonal protection strategies.

Synthesis

  • Route1
    • null|null
      39684-80-5
    • null|null
      75-31-0
    • ~77%
    • In-stock
      tert-Butyl (2-(isopropylamino)ethyl)carbamate|CS-0309306
      320580-88-9

    References

    • Li, Hongbo; Hao, Meng-An; Wang, Liping; Liang, Wu; Chen, Kai Organic Preparations and Procedures International, 2009 , vol. 41, # 4 p. 301 - 307
  • Route2
    • null|null
      19522-67-9
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • ~97%
    • In-stock
      tert-Butyl (2-(isopropylamino)ethyl)carbamate|CS-0309306
      320580-88-9

    References

    • Lee, Dae Woo; Ha, Hyun-Joon; Lee, Won Koo Synthetic Communications, 2007 , vol. 37, # 5 p. 737 - 742
  • Route3
    • null|null
      19522-67-9
    • In-stock
      N-((tert-Butoxycarbonyl)oxy)benzimidoyl cyanide|CS-W012697
      58632-95-4
    • ~81%
    • In-stock
      tert-Butyl (2-(isopropylamino)ethyl)carbamate|CS-0309306
      320580-88-9

    References

    • Corelli, Federico; Botta, Maurizio; Lossani, Andrea; Pasquini, Serena; Spadari, Silvio; Focher, Federico Farmaco, 2004 , vol. 59, # 12 p. 987 - 992

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.5091
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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