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CS-W001157 4
Total: USD 88.00

4-Amino-1-naphthoic acid

  • CAS No. 32018-87-4

  • Cat. No. CS-W022066
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Amino-1-naphthoic acid|CS-W022066

Structure of 32018-87-4

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General Information

  • CAS No. 32018-87-4
  • Cat. No. CS-W022066
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉NO₂
  • Molecular Weight 187.20
  • Synonym(s) None
  • SMILES O=C(O)C1=C2C=CC=CC2=C(N)C=C1

Description

4-Amino-1-naphthoic acid features a naphthalene core with strategically positioned amino and carboxylic acid groups, enabling versatile conjugation in dye synthesis and pharmaceutical intermediates. The electron-donating amino substituent enhances reactivity at the peri-position, while the carboxylic acid facilitates salt formation and solubility tuning under standard conditions.

Application

4-Amino-1-naphthoic acid serves as a versatile building block in synthetic organic chemistry, enabling access to functionalized naphthalene scaffolds through standard amine and carboxylic acid transformations. Its dual functionality facilitates coupling reactions, derivatization, and incorporation into heterocyclic systems. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Qian, Yimin; Marugan, Juan Jose; Fossum, Renae D.; Vogt, Andreas; Sebti, Said M.; Hamilton, Andrew D. Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 12 p. 3011 - 3024
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    • 1-Acetamidonaphthalene|CS-0207171
      575-36-0
    • ~%
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      4-Amino-1-naphthoic acid|CS-W022066
      32018-87-4

    References

    • Kisber; Glagolewa Zhurnal Obshchei Khimii, 1953 , vol. 23, p. 1028,1030; engl. Ausg. S. 1077, 1079
  • Route3
    • 4-Nitro-1-naphthoic acid|CS-W022225
      1975-43-5
    • ~%
    • In-stock
      4-Amino-1-naphthoic acid|CS-W022066
      32018-87-4

    References

    • Sergiewskaja; Preobrashenskaja Zhurnal Obshchei Khimii, 1940 , vol. 10, p. 950,954, 955 Chem. Zentralbl., 1940 , vol. 111, # II p. 3025

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   2.1202
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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