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CS-W001157 4
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4-(4-Bromophenoxy)aniline

  • CAS No. 31465-35-7

  • Cat. No. CS-0207391
  • Purity≥98%
  • MDL No.MFCD00459611

*For research and further manufacturing use only, not for direct human use.

4-(4-Bromophenoxy)aniline|CS-0207391

Structure of 31465-35-7

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General Information

  • CAS No. 31465-35-7
  • Cat. No. CS-0207391
  • Purity ≥98%
  • MDL No. MFCD00459611
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀BrNO
  • Molecular Weight 264.12
  • Synonym(s) benzenamine,4-(4-bromophenoxy)
  • SMILES C1=C(C=CC(=C1)OC2=CC=C(C=C2)N)Br

Description

4-(4-Bromophenoxy)aniline features a brominated aromatic ring linked via an ether bond to an aniline moiety, delivering enhanced electronic modulation and synthetic versatility. This structure enables efficient coupling reactions in pharmaceutical and materials synthesis, where robust functional group tolerance and thermal stability are required.

Application

4-(4-Bromophenoxy)aniline serves as a versatile building block for the synthesis of pharmaceutical intermediates and functional materials. Its structure combines a brominated aromatic ring with a phenoxy-linked aniline moiety, enabling facile Suzuki-Miyaura and Ullmann coupling reactions. The compound exhibits good bench stability, tolerates diverse reaction conditions, and facilitates the construction of complex heterocyclic systems and biaryl scaffolds in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Baliah,V.; Kanagasabapathy,V.M. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978 , vol. 16, p. 810 - 814
  • Route2
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    • In-stock
      4-(4-Bromophenoxy)aniline|CS-0207391
      31465-35-7

    References

    • Suter Journal of the American Chemical Society, 1929 , vol. 51, p. 2584
  • Route3

    References

    • Suter Journal of the American Chemical Society, 1929 , vol. 51, p. 2584

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   3.8236
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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