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CS-W001157 4
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cis-Cyclobutane-1,2-dicarboxylic acid monomethyl ester

  • CAS No. 31420-52-7

  • Cat. No. CS-0055520
  • Purity≥98%
  • MDL No.None
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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

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*For research and further manufacturing use only, not for direct human use.

cis-Cyclobutane-1,2-dicarboxylic acid monomethyl ester|CS-0055520

Structure of 31420-52-7

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Description

This monomethyl ester of cis-cyclobutane-1,2-dicarboxylic acid features a rigid, strained cyclobutane core that imparts distinct stereochemical control in synthetic transformations. The ester group enhances solubility in organic solvents while preserving the molecule’s conformational integrity, enabling reliable use in asymmetric synthesis and cycloaddition reactions.

Application

cis-Cyclobutane-1,2-dicarboxylic acid monomethyl ester serves as a valuable chiral building block in synthetic organic chemistry, enabling access to constrained cyclic architectures through standard functional group manipulations. Its defined stereochemistry and bench-stable ester functionality facilitate selective derivatization, including hydrolysis, coupling reactions, and cyclization protocols. The molecule functions effectively in the synthesis of heterocyclic scaffolds and bioactive analogs where rigid cyclobutane motifs are required for conformational control.

General Information

  • CAS No. 31420-52-7
  • Cat. No. CS-0055520
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀O₄
  • Molecular Weight 158.15
  • Synonym(s) 2-(Methoxycarbonyl)cyclobutanecarboxylic acid
  • SMILES O=C([C@H]1[C@@H](C(O)=O)CC1)OC

Computational Chemistry Data

  • TPSA   63.6
  • LogP   0.2702
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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