Lot numbers can be found on the outside label of a product:
7-Chloro-4-quinazolinol
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CAS No. 31374-18-2
- Cat. No. CS-B0992
- Purity≥98%
- MDL No.MFCD00115130
*For research and further manufacturing use only, not for direct human use.
Structure of 31374-18-2
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General Information
- CAS No. 31374-18-2
- Cat. No. CS-B0992
- Purity ≥98%
- MDL No. MFCD00115130
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₅ClN₂O
- Molecular Weight 180.59
- Synonym(s) 7-chloroquinazolin-4(1H)-one
- SMILES O=C1NC=NC2=C1C=CC(Cl)=C2
Description
7-Chloro-4-quinazolinol is a bench-stable heterocyclic scaffold featuring a chlorine substituent at the 7-position and a hydroxyl group at the 4-position, enabling direct functionalization. This electron-deficient core integrates readily into kinase inhibitor architectures and serves as a key building block for targeted therapeutics.
Application
7-Chloro-4-quinazolinol serves as a versatile building block in medicinal chemistry, enabling the synthesis of kinase inhibitors and other bioactive heterocycles. Its well-defined reactivity facilitates nucleophilic substitution at the C7 position and functionalization at the N1 or C4 positions. The molecule exhibits good bench stability and compatibility with standard coupling protocols, supporting efficient access to diverse quinazoline-based scaffolds in drug discovery programs.
Synthesis
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Route1
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In-stock
5900-59-4 - ~77%
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In-stock
31374-18-2
References
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Japan Energy Corporation Patent: EP1229025 A1, 2002 ;
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Route2
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77287-34-4 -
89-77-0 - ~97%
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In-stock
31374-18-2
References
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Mitsubishi Gas Chemical Company, Inc. Patent: EP1997812 A1, 2008 ; Location in patent: Page/Page column 8 ;
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Route3
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77287-34-4
- ~87%
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In-stock
31374-18-2
References
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Cai, Xiong; Qian, Changgeng; Zhai, Haixiao Patent: US2009/76022 A1, 2009 ; Location in patent: Page/Page column 74 ; US 20090076022 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 45.75
- LogP 1.5765
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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