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CS-W001157 4
Total: USD 88.00

(4-Methoxy-2-(trifluoromethyl)phenyl)boronic acid

  • CAS No. 313546-16-6

  • Cat. No. CS-W014759
  • Purity≥97%
  • MDL No.MFCD03095346

*For research and further manufacturing use only, not for direct human use.

(4-Methoxy-2-(trifluoromethyl)phenyl)boronic acid|CS-W014759

Structure of 313546-16-6

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General Information

  • CAS No. 313546-16-6
  • Cat. No. CS-W014759
  • Purity ≥97%
  • MDL No. MFCD03095346
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BF₃O₃
  • Molecular Weight 219.95
  • Synonym(s) Boronic acid, B-[4-methoxy-2-(trifluoromethyl)phenyl]-
  • SMILES COC1=CC(=C(C=C1)B(O)O)C(F)(F)F

Description

This boronic acid features a methoxy-substituted aryl group paired with a trifluoromethyl moiety, delivering enhanced stability and solubility in organic media. The electron-deficient ring facilitates efficient Suzuki-Miyaura coupling under mild conditions, enabling reliable C–C bond formation in complex molecule synthesis.

Application

(4-Methoxy-2-(trifluoromethyl)phenyl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the methoxy substituent provides favorable electronic modulation. The boronic acid functionality offers excellent bench stability, straightforward purification, and broad functional group tolerance, making it ideal for iterative synthesis in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.3938
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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