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Structure of 313339-35-4
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4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid features a highly reactive pyrimidine core functionalized with two chlorine atoms at C4 and C6, a methylthio group at C2, and a carboxylic acid at C5. This combination enables direct coupling in heterocyclic synthesis, particularly for constructing bioactive nucleoside analogs and kinase inhibitors under mild conditions. The molecule’s electron-deficient nature enhances its utility in transition-metal-catalyzed cross-coupling reactions.
4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its dichloro substitution pattern facilitates nucleophilic displacement reactions, while the methylthio and carboxylic acid groups offer orthogonal reactivity for downstream functionalization. The compound exhibits good bench stability and is amenable to standard purification methods, making it well-suited for use in multi-step syntheses of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: