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CS-W001157 4
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4-Fluoro-1H-indole-7-carboxylic acid

  • CAS No. 313337-34-7

  • Cat. No. CS-0043683
  • Molecule weight179.15
  • Purity≥98%
  • MDL No.MFCD11845609

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-1H-indole-7-carboxylic acid|CS-0043683

Structure of 313337-34-7

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General Information

  • CAS No. 313337-34-7
  • Cat. No. CS-0043683
  • Purity ≥98%
  • MDL No. MFCD11845609
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆FNO₂
  • Molecular Weight 179.15
  • Synonym(s) 7-Carboxy-4-fluoro-1H-indole
  • SMILES O=C(C1=CC=C(F)C2=C1NC=C2)O

Description

4-Fluoro-1H-indole-7-carboxylic acid features a fluorinated indole core with a carboxylic acid group at the C7 position, enabling direct incorporation into bioactive molecule scaffolds. The electron-withdrawing fluorine substituent enhances metabolic stability and modulates electronic properties for medicinal chemistry applications. This bench-stable derivative serves as a key building block in the synthesis of targeted therapeutics and functional materials.

Application

4-Fluoro-1H-indole-7-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a fluorinated indole scaffold into bioactive molecules. The carboxylic acid group facilitates amide bond formation and derivatization under standard coupling conditions, while the 4-fluoro substitution enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions reliably in peptide coupling, heterocycle synthesis, and conjugation workflows for API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   2.0052
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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