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(R)-2-Hydroxy-2-(p-tolyl)acetic acid

  • CAS No. 31284-89-6

  • Cat. No. CS-0186127
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-2-Hydroxy-2-(p-tolyl)acetic acid|CS-0186127

Structure of 31284-89-6

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General Information

  • CAS No. 31284-89-6
  • Cat. No. CS-0186127
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₃
  • Molecular Weight 166.17
  • Synonym(s) (R)-4-Methylmandelic acid
  • SMILES CC1=CC=C(C=C1)[C@H](C(=O)O)O

Description

(R)-2-Hydroxy-2-(p-tolyl)acetic acid features a chiral α-hydroxy carboxylic acid scaffold with a para-tolyl group enhancing electronic stability and solubility. This bench-stable, moisture-tolerant reagent integrates readily into asymmetric synthesis workflows, serving as a key chiral auxiliary for stereoselective transformations.

Application

(R)-2-Hydroxy-2-(p-tolyl)acetic acid serves as a valuable chiral building block in asymmetric synthesis, enabling the construction of biologically relevant scaffolds through established enantioselective transformations. Its bench-stable nature and well-defined stereochemistry facilitate reliable use in medicinal chemistry and process development. The molecule functions effectively in coupling reactions and acts as a precursor to α-hydroxy carboxylic acid derivatives with high synthetic utility.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   1.11302
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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