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CS-W001157 4
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Vonoprazan impurity 7

  • CAS No. 312307-38-3

  • Cat. No. CS-0164567
  • Molecule weight202.19
  • Purity≥95%
  • MDL No.MFCD28404602

*For research and further manufacturing use only, not for direct human use.

Vonoprazan impurity 7|CS-0164567

Structure of 312307-38-3

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General Information

  • CAS No. 312307-38-3
  • Cat. No. CS-0164567
  • Purity ≥95%
  • MDL No. MFCD28404602
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇FN₂O
  • Molecular Weight 202.19
  • Synonym(s) None
  • SMILES C1=CC=C(C(=C1)C(=O)CC(C#N)C#N)F

Description

Vonoprazan Impurity exhibits a fluorinated aromatic moiety linked to a malononitrile core, enabling precise structural analysis in pharmaceutical quality control. The compound features enhanced stability under standard handling conditions and integrates readily into synthetic workflows requiring trace impurity monitoring.

Application

2-(2-(2-Fluorophenyl)-2-oxoethyl)malononitrile serves as a well-characterized impurity in the synthesis of vonoprazan, a gastric proton pump inhibitor. The molecule features a malononitrile moiety flanked by a ketone-bearing aryl-substituted alkyl chain, enabling predictable reactivity in nucleophilic addition and condensation reactions. Its bench-stable crystalline form facilitates purification and analytical characterization, making it a relevant reference standard for process and quality control in pharmaceutical manufacturing.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317
Precautionary Statements : P261-P272-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.65
  • LogP   2.06186
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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