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6-Methoxypyridine-3-sulfonyl chloride

  • CAS No. 312300-42-8

  • Cat. No. CS-0082302
  • Purity≥98%
  • MDL No.MFCD06739108

*For research and further manufacturing use only, not for direct human use.

6-Methoxypyridine-3-sulfonyl chloride|CS-0082302

Structure of 312300-42-8

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General Information

  • CAS No. 312300-42-8
  • Cat. No. CS-0082302
  • Purity ≥98%
  • MDL No. MFCD06739108
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO₃S
  • Molecular Weight None
  • Synonym(s) 6-Methoxypyridine-3-sulphonyl chloride
  • SMILES COC1=CC=C(S(Cl)(=O)=O)C=N1

Description

6-Methoxypyridine-3-sulfonyl chloride is a bench-stable, moisture-tolerant sulfonyl chloride reagent featuring a pyridine scaffold with orthogonal functional handles. The methoxy group enhances solubility in polar organic solvents, while the sulfonyl chloride moiety enables efficient coupling to amines and thiols under mild conditions. This reagent streamlines the synthesis of sulfonamide and thioether derivatives in medicinal chemistry workflows.

Application

6-Methoxypyridine-3-sulfonyl chloride serves as a versatile sulfonylating agent for the synthesis of sulfonamide derivatives. Its reactivity enables efficient coupling with amines under mild conditions, offering high functional group tolerance and straightforward purification. The methoxy-substituted pyridine scaffold enhances solubility and stability, making it well-suited for medicinal chemistry applications and scale-up in API intermediate development.

Synthesis

  • Route1

    References

    • INTERMUNE, INC. Patent: US2009/318455 A1, 2009 ; Location in patent: Page/Page column 94-95 ;
  • Route2

    References

    • Synlett, , # 8 art. no. U00411ST, p. 1117 - 1120

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   56.26
  • LogP   1.0177
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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