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CS-W001157 4
Total: USD 88.00

5-Fluoropicolinaldehyde

  • CAS No. 31181-88-1

  • Cat. No. CS-W004870
  • Purity≥97%
  • MDL No.MFCD07781242

*For research and further manufacturing use only, not for direct human use.

5-Fluoropicolinaldehyde|CS-W004870

Structure of 31181-88-1

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General Information

  • CAS No. 31181-88-1
  • Cat. No. CS-W004870
  • Purity ≥97%
  • MDL No. MFCD07781242
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO
  • Molecular Weight 125.10
  • Synonym(s) 5-fluoropyridine-2-carbaldehyde
  • SMILES O=CC1=NC=C(F)C=C1

Application

5-Fluoropicolinaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-aldehyde functionality facilitates efficient imine formation and reductive amination, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard functional group transformations, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • Ethyl 5-fluoropicolinate|CS-0315150
      148541-70-2
    • ~56%
    • In-stock
      5-Fluoropicolinaldehyde|CS-W004870
      31181-88-1

    References

    • ASTRAZENECA AB; NPS PHARMACEUTICALS, INC. Patent: WO2004/14902 A2, 2004 ; Location in patent: Page 42 ; WO 2004/014902 A2
  • Route2

    References

    • ASTRAZENECA AB; NPS PHARMACEUTICALS, INC. Patent: WO2005/66155 A1, 2005 ; Location in patent: Page/Page column 22-23 ; WO 2005/066155 A1
  • Route3
    • In-stock
      2-Bromo-5-fluoropyridine|CS-W008965
      41404-58-4
    • null|null
      68-12-2
    • ~%
    • In-stock
      5-Fluoropicolinaldehyde|CS-W004870
      31181-88-1

    References

    • US2007/105904 A1, ; Page/Page column 87 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.0332
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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