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CS-W001157 4
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(S)-2-Amino-3-(2,4-difluorophenyl)propanoic acid

  • CAS No. 31105-93-8

  • Cat. No. CS-0063150
  • Molecule weight201.17
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-2-Amino-3-(2,4-difluorophenyl)propanoic acid|CS-0063150

Structure of 31105-93-8

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General Information

  • CAS No. 31105-93-8
  • Cat. No. CS-0063150
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉F₂NO₂
  • Molecular Weight 201.17
  • Synonym(s) 2,4-Difluoro-L-Phenylalanine
  • SMILES N[C@@H](CC1=CC=C(F)C=C1F)C(O)=O

Description

(S)-2-Amino-3-(2,4-difluorophenyl)propanoic acid is a chiral building block featuring a sterically hindered alpha-amino acid scaffold with dual fluorine substituents. The para-fluoro and meta-fluoro groups enhance electron-withdrawal and metabolic stability, while the (S)-configuration supports stereoselective incorporation into bioactive peptides. This bench-stable derivative enables efficient access to fluorinated analogs in medicinal chemistry campaigns.

Application

(S)-2-Amino-3-(2,4-difluorophenyl)propanoic acid serves as a key chiral building block for the synthesis of bioactive molecules, particularly in medicinal chemistry. Its well-defined stereochemistry and functional group compatibility enable reliable incorporation into peptide-like scaffolds and heterocyclic frameworks. The molecule exhibits excellent bench stability and facilitates efficient coupling reactions, making it a practical choice for both academic research and industrial process development.

Synthesis

  • Route1
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      266360-48-9
    • ~%
    • In-stock
      (S)-2-Amino-3-(2,4-difluorophenyl)propanoic acid|CS-0063150
      31105-93-8
    • null|null
      266360-54-7

    References

    • Tetrahedron Letters, , vol. 41, # 6 p. 923 - 927
  • Route2
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      23915-07-3
    • ~%
    • In-stock
      (S)-2-Amino-3-(2,4-difluorophenyl)propanoic acid|CS-0063150
      31105-93-8

    References

    • Tetrahedron Letters, , vol. 41, # 6 p. 923 - 927
  • Route3
    • null|null
      266360-44-5
    • ~%
    • In-stock
      (S)-2-Amino-3-(2,4-difluorophenyl)propanoic acid|CS-0063150
      31105-93-8

    References

    • Tetrahedron Letters, , vol. 41, # 6 p. 923 - 927

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.9192
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   3

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