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CS-W001157 4
Total: USD 88.00

ETHYL 3-HYDRAZINO-3-OXOPROPIONATE

  • CAS No. 30866-24-1

  • Cat. No. CS-W004175
  • Purity≥95%
  • MDL No.MFCD00134484

*For research and further manufacturing use only, not for direct human use.

ETHYL 3-HYDRAZINO-3-OXOPROPIONATE|CS-W004175

Structure of 30866-24-1

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General Information

  • CAS No. 30866-24-1
  • Cat. No. CS-W004175
  • Purity ≥95%
  • MDL No. MFCD00134484
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀N₂O₃
  • Molecular Weight 146.14
  • Synonym(s) Ethyl 3-hydrazino-3-oxopropionate
  • SMILES CCOC(=O)CC(=O)NN

Description

Ethyl 3-hydrazinyl-3-oxopropanoate features a reactive hydrazino group paired with an electrophilic carbonyl, enabling efficient coupling in heterocyclic synthesis. This bifunctional reagent integrates readily into complex molecular architectures under mild conditions.

Application

Ethyl 3-hydrazinyl-3-oxopropanoate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrazole and triazole scaffolds via cyclocondensation reactions. The hydrazino carbonyl motif exhibits high reactivity with electrophiles, including aldehydes, ketones, and activated esters, under mild conditions. Its bench-stable nature and compatibility with common functional groups facilitate straightforward purification and integration into multi-step synthetic sequences.

Synthesis

  • Route1
    • null|null
      105-53-3
    • ~36%
    • In-stock
      ETHYL 3-HYDRAZINO-3-OXOPROPIONATE|CS-W004175
      30866-24-1

    References

    • Di Braccio, Mario; Grossi, Giancarlo; Roma, Giorgio; Piras, Daniela; Mattioli, Francesca; Gosmar, Marzia European Journal of Medicinal Chemistry, 2008 , vol. 43, # 3 p. 584 - 594
  • Route2
    • null|null
      137786-67-5
    • ~30%
    • In-stock
      ETHYL 3-HYDRAZINO-3-OXOPROPIONATE|CS-W004175
      30866-24-1
    • null|null
      105-53-3

    References

    • Synthetic Communications, , vol. 32, # 24 p. 3767 - 3777
  • Route3

    References

    • Chemistry of Heterocyclic Compounds, , vol. 46, # 1 p. 37 - 49

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   81.42
  • LogP   -1.0705
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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