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CS-W001157 4
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Methyl 5-hydroxypyridine-2-carboxylate

  • CAS No. 30766-12-2

  • Cat. No. CS-W005963
  • Molecule weightNone
  • Purity≥96%
  • MDL No.MFCD05256426

*For research and further manufacturing use only, not for direct human use.

Methyl 5-hydroxypyridine-2-carboxylate|CS-W005963

Structure of 30766-12-2

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General Information

  • CAS No. 30766-12-2
  • Cat. No. CS-W005963
  • Purity ≥96%
  • MDL No. MFCD05256426
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O=C(C1=NC=C(O)C=C1)OC

Description

Methyl 5-hydroxypyridine-2-carboxylate features a hydroxyl group at the 5-position and an ester-functionalized pyridine ring, enabling direct incorporation into heterocyclic synthesis. The electron-rich pyridine core supports efficient metal-catalyzed coupling reactions, while the pendant hydroxyl offers sites for derivatization or hydrogen bonding in molecular recognition systems.

Application

Methyl 5-hydroxypyridine-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds. The ortho-hydroxyester functionality facilitates directed metalation and subsequent functionalization, while the methyl ester supports straightforward derivatization via hydrolysis or reduction. Bench-stable and compatible with common coupling protocols, it functions effectively in medicinal chemistry campaigns requiring pyridine-based pharmacophores.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.5738
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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