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CS-W001157 4
Total: USD 88.00

5-Methoxyquinolin-8-amine

  • CAS No. 30465-68-0

  • Cat. No. CS-W007287
  • Purity≥95%
  • MDL No.MFCD01593679

*For research and further manufacturing use only, not for direct human use.

5-Methoxyquinolin-8-amine|CS-W007287

Structure of 30465-68-0

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General Information

  • CAS No. 30465-68-0
  • Cat. No. CS-W007287
  • Purity ≥95%
  • MDL No. MFCD01593679
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀N₂O
  • Molecular Weight 174.20
  • Synonym(s) None
  • SMILES NC1=C2N=CC=CC2=C(OC)C=C1

Application

5-Methoxyquinolin-8-amine serves as a versatile building block in medicinal chemistry, enabling the construction of quinoline-based scaffolds with enhanced solubility and metabolic stability. Its ortho-amino and methoxy functionalities facilitate downstream functionalization via palladium-catalyzed couplings, electrophilic substitution, and reductive amination. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step synthesis of kinase inhibitors and other bioactive heterocycles.

Synthesis

  • Route1

    References

    • Hitomi, Yutaka; Arakawa, Kengo; Kodera, Masahito Chemistry - A European Journal, 2013 , vol. 19, # 43 p. 14697 - 14701

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.8256
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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