Lot numbers can be found on the outside label of a product:
Diethyl 2-(1-ethoxyethylidene)malonate
-
CAS No. 3044-06-2
- Cat. No. CS-0145368
- Purity≥95%
- MDL No.MFCD22575006
*For research and further manufacturing use only, not for direct human use.
Structure of 3044-06-2
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 3044-06-2
- Cat. No. CS-0145368
- Purity ≥95%
- MDL No. MFCD22575006
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₈O₅
- Molecular Weight 230.26
- Synonym(s) Propanedioic acid, 2-(1-ethoxyethylidene)-, 1,3-diethyl ester
- SMILES O=C(OCC)/C(C(OCC)=O)=C(OCC)\C
Description
Diethyl 2-(1-ethoxyethylidene)malonate is a bench-stable, moisture-tolerant diester that integrates a reactive ethoxy-substituted alkene. This structure enables efficient Michael addition and conjugate addition protocols in synthetic workflows. The electron-deficient double bond facilitates nucleophilic capture under mild conditions, delivering functionalized malonate derivatives with high regiocontrol.
Application
Diethyl 2-(1-ethoxyethylidene)malonate serves as a versatile diester building block for heterocyclic synthesis, enabling efficient access to substituted pyrroles and other nitrogen-containing scaffolds via multicomponent reactions. Its α,β-unsaturated enol ether functionality facilitates conjugate additions and cycloadditions under mild conditions, while the ethoxy substituent enhances bench stability and simplifies purification. Functions reliably in standard synthetic workflows requiring controlled electrophilic reactivity and orthogonal functional group compatibility.
Synthesis
-
Route1
-
78-39-7 -
105-53-3
- ~67%
-
In-stock
3044-06-2
References
-
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A. Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
-
-
Route2
-
In-stock
570-08-1 -
78-39-7
- ~54%
-
In-stock
3044-06-2
References
-
GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas Patent: WO2013/96153 A1, 2013 ; Location in patent: Page/Page column 162 ;
-
-
Route3
-
64-67-5
-
In-stock
570-08-1
- ~65%
-
In-stock
3044-06-2
References
-
Suzuki, Naoyuki; Shiota, Takeshi; Watanabe, Fumihiko; Haga, Norihiro; Murashi, Takami; Ohara, Takafumi; Matsuo, Kenji; Oomori, Naoki; Yari, Hiroshi; Dohi, Keiji; Inoue, Makiko; Iguchi, Motofumi; Sentou, Jyunko; Wada, Tooru Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1601 - 1606
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 61.83
- LogP 1.4231
- H_Acceptors 5
- H_Donors 0
- Rotatable_Bonds 6
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- Diethyl 2-(1-ethoxyethylidene)malonate sigmaDiethyl 2-(1-ethoxyethylidene)malonate manufacturerDiethyl 2-(1-ethoxyethylidene)malonate priceDiethyl 2-(1-ethoxyethylidene)malonate structureDiethyl 2-(1-ethoxyethylidene)malonate SDSbuy Diethyl 2-(1-ethoxyethylidene)malonateDiethyl 2-(1-ethoxyethylidene)malonate supplierDiethyl 2-(1-ethoxyethylidene)malonate usesDiethyl 2-(1-ethoxyethylidene)malonate molecular weightprice of Diethyl 2-(1-ethoxyethylidene)malonateDiethyl 2-(1-ethoxyethylidene)malonate chemical name formula of Diethyl 2-(1-ethoxyethylidene)malonate