Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-((tert-Butoxycarbonyl)amino)-4-methylthiazole-5-carboxylic acid

  • CAS No. 302963-94-6

  • Cat. No. CS-0153421
  • Purity≥95%
  • MDL No.MFCD01631191

*For research and further manufacturing use only, not for direct human use.

2-((tert-Butoxycarbonyl)amino)-4-methylthiazole-5-carboxylic acid|CS-0153421

Structure of 302963-94-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 302963-94-6
  • Cat. No. CS-0153421
  • Purity ≥95%
  • MDL No. MFCD01631191
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄N₂O₄S
  • Molecular Weight 258.29
  • Synonym(s) N-Boc-amino-4-methylthiazole-5-carboxylic acid
  • SMILES CC1=C(SC(NC(OC(C)(C)C)=O)=N1)C(O)=O

Description

This thiazole derivative features a tert-butoxycarbonyl-protected amine and a methyl-substituted thiazole ring, enabling direct incorporation into peptide synthesis. The carboxylic acid group supports conjugation via standard coupling protocols, while the Boc moiety ensures stability during handling.

Application

2-((tert-Butoxycarbonyl)amino)-4-methylthiazole-5-carboxylic acid serves as a versatile building block for thiazole-based heterocycles, enabling direct functionalization at the 5-position and stable protection of the amine at the 2-position. Its bench-stable tert-butyl ester group facilitates purification and orthogonal deprotection, while the carboxylic acid supports amide coupling and derivatization in standard peptide and medicinal chemistry workflows.

Synthesis

  • Route1
    • Ethyl 2-((tert-butoxycarbonyl)amino)-4-methylthiazole-5-carboxylate|CS-0660630
      244236-52-0
    • ~86%
    • In-stock
      2-((tert-Butoxycarbonyl)amino)-4-methylthiazole-5-carboxylic acid|CS-0153421
      302963-94-6

    References

    • Das, Jagabandhu; Padmanabha, Ramesh; Chen, Ping; Norris, Derek J.; Doweyko, Arthur M.P.; Barrish, Joel C.; Wityak, John; Lombardo, Louis J.; Lee, Francis Y.F. Patent: US2004/54186 A1, 2004 ; Location in patent: Page 20 ; US 20040054186 A1
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 23 p. 6819 - 6832
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 23 p. 6819 - 6832

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   88.52
  • LogP   2.49672
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 302963-94-6 sigma302963-94-6 manufacturer302963-94-6 price302963-94-6 structure302963-94-6 SDSbuy 302963-94-6302963-94-6 supplier302963-94-6 uses302963-94-6 molecular weightprice of 302963-94-6302963-94-6 chemical name formula of 302963-94-6
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label