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CS-W001157 4
Total: USD 88.00

(4-Cyclopropylphenyl)boronic acid

  • CAS No. 302333-80-8

  • Cat. No. CS-0040763
  • Purity≥98%
  • MDL No.MFCD01309064

*For research and further manufacturing use only, not for direct human use.

(4-Cyclopropylphenyl)boronic acid|CS-0040763

Structure of 302333-80-8

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General Information

  • CAS No. 302333-80-8
  • Cat. No. CS-0040763
  • Purity ≥98%
  • MDL No. MFCD01309064
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BO₂
  • Molecular Weight 161.99
  • Synonym(s) 4-Cyclopropylphenylboronic acid
  • SMILES OB(C1=CC=C(C2CC2)C=C1)O

Description

(4-Cyclopropylphenyl)boronic acid features a cyclopropyl group that enhances metabolic stability and lipophilicity, improving cellular permeability. The boronic acid moiety enables reliable Suzuki-Miyaura cross-coupling under standard conditions, delivering arylated products with high functional group tolerance. This bench-stable reagent integrates seamlessly into complex molecule synthesis workflows.

Application

(4-Cyclopropylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. Its cyclopropyl substituent imparts enhanced metabolic stability and favorable lipophilicity profiles, making it particularly valuable for medicinal chemistry applications. The boronic acid moiety exhibits excellent bench stability, tolerance to diverse functional groups, and straightforward purification via crystallization or silica gel chromatography.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.2438
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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