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tert-Butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

  • CAS No. 301226-27-7

  • Cat. No. CS-0000747
  • Purity≥97%
  • MDL No.MFCD11100196

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate|CS-0000747

Structure of 301226-27-7

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General Information

  • CAS No. 301226-27-7
  • Cat. No. CS-0000747
  • Purity ≥97%
  • MDL No. MFCD11100196
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₁NO₄
  • Molecular Weight 255.31
  • Synonym(s) tert-Butyl-2-oxo-1-oxa-8-azaspiro[4.5]decan-8-carboxylat
  • SMILES O=C(OC(C)(C)C)N(CC1)CCC12OC(CC2)=O

Synthesis

  • Route1
    • tert-butyl 4-(3-ethoxy-3-oxopropyl)-4-hydroxypiperidine-1-carboxylate|CS-0001505
      374794-91-9
    • ~90%
    • In-stock
      tert-Butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate|CS-0000747
      301226-27-7

    References

    • MERCK SHARP and DOHME LIMITED Patent: WO2004/78750 A1, 2004 ; Location in patent: Page 79-80 ; WO 2004/078750 A1
  • Route2

    References

    • Meyers, Marvin J.; Long, Scott A.; Pelc, Matthew J.; Wang, Jane L.; Bowen, Scott J.; Walker, Mark C.; Schweitzer, Barbara A.; Madsen, Heather M.; Tenbrink, Ruth E.; McDonald, Joseph; Smith, Sarah E.; Foltin, Susan; Beidler, David; Thorarensen, Atli Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6538 - 6544
  • Route3
    • null|null
      79099-07-3
    • ~%
    • In-stock
      tert-Butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate|CS-0000747
      301226-27-7

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 13 p. 1759 - 1762

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.84
  • LogP   2.0931
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   0

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