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CS-W001157 4
Total: USD 88.00

2,3-Dihydro-1H-indene-5-carbaldehyde

  • CAS No. 30084-91-4

  • Cat. No. CS-W007269
  • Purity≥95%
  • MDL No.MFCD00086208

*For research and further manufacturing use only, not for direct human use.

2,3-Dihydro-1H-indene-5-carbaldehyde|CS-W007269

Structure of 30084-91-4

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General Information

  • CAS No. 30084-91-4
  • Cat. No. CS-W007269
  • Purity ≥95%
  • MDL No. MFCD00086208
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O
  • Molecular Weight 146.19
  • Synonym(s) INDAN-5-CARBOXALDEHYDE
  • SMILES O=CC1=CC=C2CCCC2=C1

Description

This bench-stable aldehyde features a fused bicyclic structure with a reactive carbonyl at the 5-position, enabling direct incorporation into synthesis workflows. The electron-rich indene core enhances reactivity in nucleophilic addition and coupling reactions, while the dihydro substitution maintains compatibility with standard organic protocols.

Application

2,3-Dihydro-1H-indene-5-carbaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted indene scaffolds. Its aldehyde functionality facilitates standard transformations including reductive amination, Grignard additions, and Wittig reactions, while the fused bicyclic framework offers rigidity and defined stereochemistry. Bench-stable and amenable to purification via chromatography or crystallization, it functions reliably in multi-step syntheses targeting pharmaceutical intermediates and functional materials.

Synthesis

  • Route1
    • null|null
      721968-62-3
    • ~%
    • In-stock
      2,3-Dihydro-1H-indene-5-carbaldehyde|CS-W007269
      30084-91-4

    References

    • EP1577290 A1, ; Page/Page column 102 ;
  • Route2
    • null|null
      4885-02-3
    • In-stock
      2,3-Dihydro-1H-indene|CS-W016586
      496-11-7
    • ~96%
    • In-stock
      2,3-Dihydro-1H-indene-5-carbaldehyde|CS-W007269
      30084-91-4

    References

    • Monte, Aaron P.; Marona-Lewicka, Danuta; Cozzi, Nicholas V.; Nichols, David E. Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3700 - 3706
  • Route3
    • In-stock
      2,3-Dihydro-1H-indene|CS-W016586
      496-11-7
    • null|null
      100-97-0
    • ~82%
    • In-stock
      2,3-Dihydro-1H-indene-5-carbaldehyde|CS-W007269
      30084-91-4

    References

    • LUPIN LIMITED Patent: WO2009/109999 A1, 2009 ; Location in patent: Page/Page column 59 ; WO 2009/109999 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.9878
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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