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CS-W001157 4
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2-Fluorobenzenesulfonamide

  • CAS No. 30058-40-3

  • Cat. No. CS-W007653
  • Purity≥98%
  • MDL No.MFCD00042283

*For research and further manufacturing use only, not for direct human use.

2-Fluorobenzenesulfonamide|CS-W007653

Structure of 30058-40-3

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General Information

  • CAS No. 30058-40-3
  • Cat. No. CS-W007653
  • Purity ≥98%
  • MDL No. MFCD00042283
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO₂S
  • Molecular Weight 175.18
  • Synonym(s) Benzenesulfonamide, 2-fluoro- (9CI)
  • SMILES NS(=O)(=O)C1=C(F)C=CC=C1

Description

2-Fluorobenzenesulfonamide features a fluorinated aromatic ring paired with a sulfonamide group, delivering enhanced metabolic stability and targeted electronic properties. This combination enables efficient incorporation into bioactive scaffolds, particularly in kinase inhibitor design and medicinal chemistry optimization workflows under standard conditions.

Application

2-Fluorobenzenesulfonamide serves as a versatile building block in medicinal chemistry, enabling the introduction of both a sulfonamide and an ortho-fluoro substituent in a single, stable scaffold. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of bioactive molecules, particularly in kinase inhibitor and heterocyclic compound development.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 9 p. 2222 - 2225
  • Route2

    References

    • Advanced Synthesis and Catalysis, , vol. 344, # 10 p. 1146 - 1151
  • Route3
    • null|null
      491876-10-9
    • ~%
    • In-stock
      2-Fluorobenzenesulfonamide|CS-W007653
      30058-40-3

    References

    • Advanced Synthesis and Catalysis, , vol. 344, # 10 p. 1146 - 1151

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   0.4731
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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