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CS-W001157 4
Total: USD 88.00

1-(Difluoromethyl)-4-nitrobenzene

  • CAS No. 29848-57-5

  • Cat. No. CS-0068782
  • Purity≥96%
  • MDL No.MFCD16659620
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(Difluoromethyl)-4-nitrobenzene|CS-0068782

Structure of 29848-57-5

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Description

1-(Difluoromethyl)-4-nitrobenzene features a para-nitro group and a difluoromethyl substituent on a benzene ring, delivering strong electron-withdrawing character. This combination enhances reactivity in nucleophilic aromatic substitution processes and provides stability under standard bench conditions. The molecule integrates readily into synthetic routes requiring fluorinated aryl building blocks.

Application

1-(Difluoromethyl)-4-nitrobenzene serves as a versatile building block in medicinal chemistry, enabling direct incorporation of the difluoromethyl group—a bioisostere of hydroxyl and trifluoromethyl functionalities—into aromatic scaffolds. The molecule exhibits excellent bench stability, tolerates diverse reaction conditions, and facilitates subsequent transformations such as nucleophilic substitution and catalytic cross-coupling, making it ideal for rapid exploration of fluorinated compound libraries.

General Information

  • CAS No. 29848-57-5
  • Cat. No. CS-0068782
  • Purity ≥96%
  • MDL No. MFCD16659620
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₂
  • Molecular Weight None
  • Synonym(s) 1-Difluoromethyl-4-nitro-benzene
  • SMILES O=[N+](C1=CC=C(C(F)F)C=C1)[O-]

Computational Chemistry Data

  • TPSA   43.14
  • LogP   2.5324
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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