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Structure of 29848-57-5
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1-(Difluoromethyl)-4-nitrobenzene features a para-nitro group and a difluoromethyl substituent on a benzene ring, delivering strong electron-withdrawing character. This combination enhances reactivity in nucleophilic aromatic substitution processes and provides stability under standard bench conditions. The molecule integrates readily into synthetic routes requiring fluorinated aryl building blocks.
1-(Difluoromethyl)-4-nitrobenzene serves as a versatile building block in medicinal chemistry, enabling direct incorporation of the difluoromethyl group—a bioisostere of hydroxyl and trifluoromethyl functionalities—into aromatic scaffolds. The molecule exhibits excellent bench stability, tolerates diverse reaction conditions, and facilitates subsequent transformations such as nucleophilic substitution and catalytic cross-coupling, making it ideal for rapid exploration of fluorinated compound libraries.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: