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CS-W001157 4
Total: USD 88.00

5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine

  • CAS No. 297172-19-1

  • Cat. No. CS-W022269
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine|CS-W022269

Structure of 297172-19-1

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General Information

  • CAS No. 297172-19-1
  • Cat. No. CS-W022269
  • Purity ≥97%
  • MDL No. None
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) Imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro- (9CI)
  • SMILES C12=CN=CN1CCNC2

Description

5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine is a saturated heterocyclic scaffold featuring a fused imidazole-pyrazine core. This electron-rich, bench-stable framework serves as a key structural motif in medicinal chemistry, enabling efficient integration into bioactive molecules through modular derivatization.

Application

5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of nitrogen-rich scaffolds with enhanced metabolic stability. Its saturated core offers improved solubility and reduced lipophilicity compared to aromatic analogs, while maintaining favorable hydrogen-bonding capacity. The molecule functions effectively in amide coupling, reductive amination, and transition-metal-catalyzed transformations, facilitating rapid diversification for target-focused libraries. Bench-stable and readily purified by chromatography or recrystallization, it supports scalable synthesis and integration into multi-step synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.85
  • LogP   -0.0137
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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