Lot numbers can be found on the outside label of a product:
Methyl 4-methoxy-2-pyridinecarboxylate
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CAS No. 29681-43-4
- Cat. No. CS-0005486
- Purity≥98%
- MDL No.MFCD00956223
*For research and further manufacturing use only, not for direct human use.
Structure of 29681-43-4
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General Information
- CAS No. 29681-43-4
- Cat. No. CS-0005486
- Purity ≥98%
- MDL No. MFCD00956223
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₉NO₃
- Molecular Weight 167.16
- Synonym(s) Methyl 4-methoxypyridine-2-carboxylate
- SMILES O=C(C1=NC=CC(OC)=C1)OC
Description
Methyl 4-methoxy-2-pyridinecarboxylate features a pyridine core with strategically positioned methoxy and ester groups, enabling efficient integration into heterocyclic synthesis. The electron-donating methoxy substituent enhances reactivity at the C4 position, while the methyl ester facilitates straightforward derivatization. This compound serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and bioactive nitrogen heterocycles.
Application
Methyl 4-methoxy-2-pyridinecarboxylate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to pyridine-based heterocycles. Its ester functionality facilitates nucleophilic substitution and reduction reactions, while the methoxy group enhances solubility and modulates electronic properties. The molecule exhibits good bench stability and is compatible with standard coupling and functionalization protocols, making it valuable for medicinal chemistry and process development workflows.
Synthesis
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Route1
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In-stock
98-98-6 -
67-56-1 - ~45%
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In-stock
29681-43-4
References
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Donohoe, Timothy J.; Connolly, Matthew J.; Walton, Lesley Organic Letters, 2009 , vol. 11, # 23 p. 5562 - 5565
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Route2
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67-56-1
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53750-66-6
- ~%
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In-stock
29681-43-4
References
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Organic Preparations and Procedures International, , vol. 29, # 1 p. 117 - 122
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Route3
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29745-44-6
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67-56-1
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124-41-4
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In-stock
29681-43-4
References
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US7081461 B1, ; Page/Page column 45 ; US 7081461 B1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 48.42
- LogP 0.8768
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 2
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Key Words
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