2'-Chloro-5'-fluoroacetophenone

Name: 2'-Chloro-5'-fluoroacetophenone
Brand: ChemScene
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CAS No. 2965-16-4
Cat. No. CS-W002212
Purity≥98%
MDL No.MFCD00042574

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2'-Chloro-5'-fluoroacetophenone|CS-W002212

Structure of 2965-16-4

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General Information

CAS No. 2965-16-4
Cat. No. CS-W002212
Purity ≥98%
MDL No. MFCD00042574
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆ClFO
Molecular Weight 172.58
Synonym(s) 2-Chloro-5-fluoroacetophenone
SMILES CC(C1=C(Cl)C=CC(F)=C1)=O

Description

2'-Chloro-5'-fluoroacetophenone features a chlorinated and fluorinated aryl scaffold that imparts enhanced electron-withdrawing character, enabling efficient coupling in cross-coupling reactions. The ketone functionality serves as a direct handle for nucleophilic additions and derivatization, while the ortho-chloro substituent facilitates further functionalization via palladium-catalyzed pathways. This compound offers robust stability under standard bench conditions and is compatible with diverse synthetic workflows in medicinal chemistry and materials science.

Application

2'-Chloro-5'-fluoroacetophenone serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of biologically relevant heterocycles. Its orthogonal halogenation pattern facilitates selective cross-coupling reactions, while the acetyl group provides a handle for further functionalization. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for multi-step synthetic sequences.

Synthesis

Route1
- 352-33-0
- 75-36-5
- ~%
- In-stock
  
  2965-16-4
References
- Journal of Organic Chemistry, , vol. 26, p. 919 - 923

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 17.07
LogP 2.6817
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ketone

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2'-Chloro-5'-fluoroacetophenone

CAS No. 2965-16-4

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