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CS-W001157 4
Total: USD 88.00

12-Crown-4

  • CAS No. 294-93-9

  • Cat. No. CS-W017409
  • Molecule weight176.21
  • Purity≥95%
  • MDL No.MFCD00005103

*For research and further manufacturing use only, not for direct human use.

12-Crown-4|CS-W017409

Structure of 294-93-9

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General Information

  • CAS No. 294-93-9
  • Cat. No. CS-W017409
  • Purity ≥95%
  • MDL No. MFCD00005103
  • Storage RT, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆O₄
  • Molecular Weight 176.21
  • Synonym(s) None
  • SMILES C1COCCOCCOCCO1

Description

12-Crown-4 is a crown ether generally used as a ligand in coordination chemistry. It is also known as lithium ionophore because of its strong chelating property specific to lithium cation.12-Crown-4 can be used as: A promoter in the synthesis of poly(diethylsiloxane) (PDES) from monomer hexaethylcyclotrisiloxane using NaOH as a catalyst via anionic ring-opening polymerization. As an additive in the preparation of triarylmethane derivatives by palladium-catalyzed cross coupling reaction of aryl bromides with diarylmethane derivatives. A phase transfer catalyst in organic synthesis.

Synthesis

  • Route1
    • HO-PEG4-OH HQ|CS-1347183
      112-60-7
    • ~30%
    • In-stock
      12-Crown-4|CS-W017409
      294-93-9

    References

    • Tsunoda; Ozaki; Shirakata; Tamaoka; Yamamoto; Ito Tetrahedron Letters, 1996 , vol. 37, # 14 p. 2463 - 2466
  • Route2
    • HO-PEG4-OH HQ|CS-1347183
      112-60-7
    • ~1%
    • In-stock
      12-Crown-4|CS-W017409
      294-93-9
    • In-stock
      1,4,7,10,13,16,19,22-Octaoxacyclotetracosane|CS-0203397
      33089-37-1
    • null|null
      71092-59-6
    • null|null
      71092-61-0

    References

    • Tetrahedron, , vol. 45, # 7 p. 2201 - 2212
  • Route3

    References

    • Bulletin of the Chemical Society of Japan, , vol. 53, # 6 p. 1689 - 1693

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅱ
Hazard Statements : H330
Precautionary Statements : P260-P271-P284-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   0.0664
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   0

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