Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Pyrazolo[1,5-a]pyrimidin-5-ol

  • CAS No. 29274-22-4

  • Cat. No. CS-0036458
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Pyrazolo[1,5-a]pyrimidin-5-ol|CS-0036458

Structure of 29274-22-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 29274-22-4
  • Cat. No. CS-0036458
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅N₃O
  • Molecular Weight 135.12
  • Synonym(s) pyrazoloapyrimidinone
  • SMILES OC1=NC2=CC=NN2C=C1

Description

Pyrazolo[1,5-a]pyrimidin-5-ol features a fused heterocyclic core with a phenolic hydroxyl group, enabling hydrogen bonding and enhanced solubility in polar solvents. This scaffold exhibits robust stability under standard bench conditions and serves as a key building block in medicinal chemistry, particularly for kinase inhibitors and bioactive small molecules.

Application

Pyrazolo[1,5-a]pyrimidin-5-ol serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling rapid access to biologically active compounds through established functionalization at the C5 position. Its inherent stability and compatibility with standard coupling reactions facilitate efficient derivatization for target-focused library synthesis. The molecule functions as a key building block in the development of kinase inhibitors and other bioactive agents, offering predictable reactivity and favorable purification characteristics in routine laboratory workflows.

Synthesis

  • Route1
    • 4H-Pyrazolo[1,5-a]pyrimidin-5-one sodium salt|CS-0185462
      1224944-43-7
    • ~82%
    • In-stock
      Pyrazolo[1,5-a]pyrimidin-5-ol|CS-0036458
      29274-22-4

    References

    • Hanan, Emily J.; Van Abbema, Anne; Barrett, Kathy; Blair, Wade S.; Blaney, Jeff; Chang, Christine; Eigenbrot, Charles; Flynn, Sean; Gibbons, Paul; Hurley, Christopher A.; Kenny, Jane R.; Kulagowski, Janusz; Lee, Leslie; Magnuson, Steven R.; Morris, Claire; Murray, Jeremy; Pastor, Richard M.; Rawson, Tom; Siu, Michael; Ultsch, Mark; Zhou, Aihe; Sampath, Deepak; Lyssikatos, Joseph P. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10090 - 10107
  • Route2

    References

    • ELAN PHARMACEUTICALS, INC.; SHAM, Hing, L.; KONRADI, Andrei, W.; HOM, Roy, K.; PROBST, Gary, D.; BOWERS, Simeon; TRUONG, Anh; NEITZ, R., Jeffrey; SEALY, Jennifer; TOTH, Gergely Patent: WO2010/91310 A1, 2010 ; Location in patent: Page/Page column 141 ; WO 2010/091310 A1
  • Route3
    • In-stock
      3-Aminopyrazole|CS-D1141
      1820-80-0
    • null|null
      623-47-2
    • ~34%
    • In-stock
      Pyrazolo[1,5-a]pyrimidin-5-ol|CS-0036458
      29274-22-4

    References

    • GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling Patent: WO2013/127268 A1, 2013 ; Location in patent: Page/Page column 68 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   50.42
  • LogP   0.4349
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Pyrazolo[1,5-a]pyrimidin-5-ol sigmaPyrazolo[1,5-a]pyrimidin-5-ol manufacturerPyrazolo[1,5-a]pyrimidin-5-ol pricePyrazolo[1,5-a]pyrimidin-5-ol structurePyrazolo[1,5-a]pyrimidin-5-ol SDSbuy Pyrazolo[1,5-a]pyrimidin-5-olPyrazolo[1,5-a]pyrimidin-5-ol supplierPyrazolo[1,5-a]pyrimidin-5-ol usesPyrazolo[1,5-a]pyrimidin-5-ol molecular weightprice of Pyrazolo[1,5-a]pyrimidin-5-olPyrazolo[1,5-a]pyrimidin-5-ol chemical name formula of Pyrazolo[1,5-a]pyrimidin-5-ol
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label