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CS-W001157 4
Total: USD 88.00

Pyridine-3-sulfonamide

  • CAS No. 2922-45-4

  • Cat. No. CS-0044993
  • Purity≥95%
  • MDL No.MFCD08690712

*For research and further manufacturing use only, not for direct human use.

Pyridine-3-sulfonamide|CS-0044993

Structure of 2922-45-4

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General Information

  • CAS No. 2922-45-4
  • Cat. No. CS-0044993
  • Purity ≥95%
  • MDL No. MFCD08690712
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O₂S
  • Molecular Weight None
  • Synonym(s) pyridine-3-sulfonic acid amide
  • SMILES O=S(C1=CC=CN=C1)(N)=O

Description

Pyridine-3-sulfonamide features a sulfonamide group attached to the pyridine ring at the 3-position, enabling strong hydrogen bonding and enhanced solubility in polar solvents. This configuration supports its use as a key scaffold in medicinal chemistry for kinase inhibitors and antimicrobial agents. The molecule exhibits good thermal stability and handles well under standard bench conditions.

Application

Pyridine-3-sulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through well-established coupling reactions. Its sulfonamide group exhibits favorable solubility and hydrogen-bonding capacity, enhancing target affinity in kinase inhibitors and other pharmaceutical scaffolds. The pyridine core provides a robust platform for further functionalization, while the compound demonstrates excellent bench stability and compatibility with standard purification techniques.

Synthesis

  • Route1

    References

    • Maslankiewicz, Andrzej; Marciniec, Krzysztof; Pawlowski, Maciej; Zajdel, Pawel Heterocycles, 2007 , vol. 71, # 9 p. 1975 - 1990
  • Route2
    • Pyridine-3-sulfonyl chloride hydrochloride|CS-W019484
      42899-76-3
    • ~88%
    • In-stock
      Pyridine-3-sulfonamide|CS-0044993
      2922-45-4

    References

    • AMGEN INC. Patent: WO2009/17822 A2, 2009 ; Location in patent: Page/Page column 64 ; WO 2009/017822 A2
  • Route3
    • In-stock
      Pyridine-3-sulfonic acid|CS-W016183
      636-73-7
    • null|null
      60-29-7
    • null|null
      75-09-2
    • ~71%
    • In-stock
      Pyridine-3-sulfonamide|CS-0044993
      2922-45-4

    References

    • Schering Corporation Patent: US5684013 A1, 1997 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   73.05
  • LogP   -0.271
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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