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CS-W001157 4
Total: USD 88.00

2,6-Dichloro-3-nitropyridin-4-amine

  • CAS No. 2897-43-0

  • Cat. No. CS-W003036
  • Purity≥98%
  • MDL No.MFCD03265754

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloro-3-nitropyridin-4-amine|CS-W003036

Structure of 2897-43-0

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General Information

  • CAS No. 2897-43-0
  • Cat. No. CS-W003036
  • Purity ≥98%
  • MDL No. MFCD03265754
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂N₃O₂
  • Molecular Weight 208.00
  • Synonym(s) 4-pyridinamine, 2,6-dichloro-3-nitro-
  • SMILES O=[N+]([O-])C1=C(N)C=C(Cl)N=C1Cl

Description

2,6-Dichloro-3-nitropyridin-4-amine features a pyridine core bearing two chlorine substituents and a nitro group at C3, with an amine functionality at C4. This electron-deficient heterocycle integrates readily into cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive nitrogen-containing compounds.

Application

2,6-Dichloro-3-nitropyridin-4-amine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds via nucleophilic displacement and subsequent reduction. The dichloro substitution pattern facilitates sequential functionalization, while the nitro and amino groups provide orthogonal reactivity for downstream transformations. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for medicinal chemistry campaigns and process-scale applications.

Synthesis

  • Route1
    • null|null
      2587-03-3
    • ~99%
    • In-stock
      2,6-Dichloro-3-nitropyridin-4-amine|CS-W003036
      2897-43-0

    References

    • Xuanzhu Pharma Co., Ltd. Patent: US2012/289497 A1, 2012 ; Location in patent: Page/Page column 51; 53 ;
  • Route2

    References

    • Xuanzhu Pharma Co., Ltd. Patent: US2012/289497 A1, 2012 ;
  • Route3
    • null|null
      2587-00-0
    • ~%
    • In-stock
      2,6-Dichloro-3-nitropyridin-4-amine|CS-W003036
      2897-43-0

    References

    • Xuanzhu Pharma Co., Ltd. Patent: US2012/289497 A1, 2012 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   82.05
  • LogP   1.8788
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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