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1-(3-Aminophenyl)dihydropyrimidine-2,4(1H,3H)-dione hydrochloride

  • CAS No. 2887498-18-0

  • Cat. No. CS-0784068
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(3-Aminophenyl)dihydropyrimidine-2,4(1H,3H)-dione hydrochloride|CS-0784068

Structure of 2887498-18-0

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General Information

  • CAS No. 2887498-18-0
  • Cat. No. CS-0784068
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂ClN₃O₂
  • Molecular Weight 241.67
  • Synonym(s) None
  • SMILES O=C1NC(CCN1C2=CC=CC(N)=C2)=O.[H]Cl

Description

This dihydropyrimidine derivative features a 3-aminophenyl moiety integrated into a bench-stable, electron-rich heterocyclic scaffold. The hydrochloride salt enhances solubility and handling in aqueous reaction media, enabling efficient incorporation into pharmaceutical intermediates and bioactive molecule libraries.

Application

1-(3-Aminophenyl)dihydropyrimidine-2,4(1H,3H)-dione (hydrochloride) serves as a versatile scaffold for medicinal chemistry and heterocyclic synthesis. The compound enables efficient functionalization at the aniline nitrogen and dihydropyrimidinone core, facilitating coupling reactions and derivatization under mild conditions. Its crystalline hydrochloride salt enhances bench stability and simplifies purification, making it suitable for high-throughput screening and API intermediate development.

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   75.43
  • LogP   1.1369
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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