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*For research and further manufacturing use only, not for direct human use.
Structure of 288251-60-5
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This pyrazole derivative features a trifluoromethyl-substituted ethyl group that enhances metabolic stability and lipophilicity. The carboxylic acid moiety enables direct conjugation or salt formation, facilitating integration into bioactive scaffolds. The electron-withdrawing trifluoroethyl group modulates electronic properties of the pyrazole ring, improving binding affinity in target-directed synthesis. This compound serves as a key building block for pharmaceutical intermediates and functional materials.
1-(2,2,2-Trifluoroethyl)-1H-pyrazole-4-carboxylic acid serves as a versatile building block for medicinal chemistry and agrochemical research, enabling the incorporation of both a trifluoromethylated aliphatic chain and a polar pyrazole carboxylic acid moiety. Its stability under standard reaction conditions facilitates coupling with amines, alcohols, and other nucleophiles, while the electron-withdrawing trifluoromethyl group enhances metabolic stability and modulates pKa. The molecule functions effectively in parallel synthesis campaigns and offers predictable reactivity in amide formation, esterification, and derivatization workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: