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8-Fluoro-2-methylquinoline-4-carboxylic acid

  • CAS No. 288151-68-8

  • Cat. No. CS-0152749
  • Purity≥98%
  • MDL No.MFCD05175451

*For research and further manufacturing use only, not for direct human use.

8-Fluoro-2-methylquinoline-4-carboxylic acid|CS-0152749

Structure of 288151-68-8

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General Information

  • CAS No. 288151-68-8
  • Cat. No. CS-0152749
  • Purity ≥98%
  • MDL No. MFCD05175451
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₈FNO₂
  • Molecular Weight 205.19
  • Synonym(s) 8-Fluoro-2-methylquinoline-4-carboxylicacid
  • SMILES CC1=NC2=C(C=CC=C2F)C(=C1)C(=O)O

Description

8-Fluoro-2-methylquinoline-4-carboxylic acid features a fluorine atom at the 8-position and a methyl group at the 2-position, enhancing electronic modulation and metabolic stability. This electron-deficient quinoline scaffold integrates readily into pharmaceutical scaffolds, enabling efficient coupling in late-stage functionalization. The carboxylic acid moiety facilitates conjugation via amide or ester linkages under standard conditions.

Application

8-Fluoro-2-methylquinoline-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its orthogonal functionalization profile—combining an electron-deficient quinoline core with fluorine-directed regioselectivity and a carboxylic acid for derivatization—facilitates efficient synthesis of kinase inhibitors and other pharmaceutical candidates. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, supporting scalable route development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.38052
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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