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Structure of 288067-35-6
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4-Bromo-2-hydroxybenzonitrile features a bromine atom at the para position relative to a hydroxyl group on a benzonitrile scaffold. This electron-deficient aryl system combines enhanced reactivity with stable handling, enabling direct functionalization in cross-coupling and derivatization workflows. The phenolic hydroxyl supports hydrogen bonding and solubility modulation, while the nitrile group provides a versatile anchor for synthetic transformations.
4-Bromo-2-hydroxybenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the phenolic hydroxyl group. Its bromine and nitrile functionalities provide orthogonal handles for palladium-catalyzed cross-coupling and nucleophilic transformations. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic campaigns requiring regioselective derivatization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: