2-Bromo-5-chlorothiophene

Name: 2-Bromo-5-chlorothiophene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

SDS

CAS No. 2873-18-9
Cat. No. CS-0012608
Purity≥98%
MDL No.MFCD00014523

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HazMat Fee

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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General Information

CAS No. 2873-18-9
Cat. No. CS-0012608
Purity ≥98%
MDL No. MFCD00014523
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₂BrClS
Molecular Weight 197.48
Synonym(s) 5-Bromo-2-chlorothiophene
SMILES BrC1=CC=C(Cl)S1

Description

2-Bromo-5-chlorothiophene is a halogenated thiophene derivative featuring complementary reactive sites for cross-coupling. The bromine and chlorine substituents enable sequential functionalization, offering precise control in the synthesis of complex heteroaromatic systems. This compound serves as a key building block in pharmaceutical and materials chemistry, where tailored substitution patterns are essential.

Application

2-Bromo-5-chlorothiophene serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo and chloro substituents offer orthogonal functionalization potential, facilitating sequential derivatization. Its bench-stable nature and compatibility with standard coupling conditions make it well-suited for constructing complex thiophene-based scaffolds in medicinal chemistry and materials science applications.

Synthesis

Route1
- 96-43-5
- ~81%
- In-stock
  
  2873-18-9
References
- Goldberg, Yuri; Alper, Howard Journal of Organic Chemistry, 1993 , vol. 58, # 11 p. 3072 - 3075
Route2
- 1003-09-4
- ~77%
- In-stock
  
  2873-18-9
References
- Wen, Li; Rasmussen, Seth C. Journal of Chemical Crystallography, 2007 , vol. 37, # 6 p. 387 - 398

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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SDS
COA

Computational Chemistry Data

TPSA 0
LogP 3.164
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Thiophene compounds

Key Words

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